Terumo Cardiovascular Systems - Precision-Focused Technology
[] eCatalog [] For Clinicians [] News [] Home
[] About Us [] Contact Us [] Careers [] Site Map
Clinical Interest
Back To:
[] For Clinicians
[] Myocardial PH Management
Khuri Myocardial pH Monitoring System
Multimedia Case Studies
Patient Outcome Studies
Research Library
Patient Outcome Studies

Intraoperative Regional Myocardial Acidosis and Reduction in Long-Term Survival After Cardiac Surgery1
The authors found that reversing or avoiding acidosis in heart tissue during cardiac surgery improves long-term patient survival.

Analysis of follow-up data on 496 adult patients an average of 10 years after undergoing cardiac surgery with cardiopulmonary bypass found that pH levels in the myocardium were independently associated with long-term patient survival.

Raising the pH level from lower than threshold before aortic cross-clamp to higher than threshold during clamping increased the median survival by 40.2%.

See abstract.

Adverse 30-Day Outcomes after Cardiac Surgery: Predictive Role of Intraoperative Myocardial Acidosis2
Regional myocardial acidosis of a magnitude frequently encountered during aortic cross clamping is an independent determiner of adverse 30 day outcomes after cardiac surgery with cardiopulmonary bypass (in press).

Intraoperative regional myocardial acidosis predicts the need for inotropic support in cardiac surgery3
This is the first study to show that intraoperative regional myocardial acidosis, a preventable condition, independently determines the need for intraoperative inotropic support (INO). Increased INO is associated with greater postoperative mortality and morbidity.

See abstract.
Readmission After Cardiac Surgery: The Role of Intraoperative Myocardial Acidosis4
Regional myocardial acidosis (RMA), which is reflective of intraoperative myocardial ischemia and is also known to induce myocyte apoptosis, independently determines unplanned readmission rates within 30 days and 6 months postoperatively.

Click here to download an abstract.

1Khuri SF, Healey NA, Hossain M, Birjiniuk V, Crittenden MD, Josa Miguel, Treanor PR, Najjar SF, Kumbhani DJ. Intraoperative Regional Myocardial Acidosis and Reduction in Long-Term Survival After Cardiac Surgery. J Thorac Cardiovasc Surg 2005;129:372-81.

2Kumbhani DJ, Healey NA, Biswas KS, Birjiniuk V, Crittenden MD, Treanor PR, Khuri SF. Adverse 30-Day Outcomes after Cardiac Surgery: Predictive Role of Intraoperative Myocardial Acidosis. Ann Thorac Surg; 2005 (in press).

3Kumbhani DJ, Healey NA, Birjiniuk V, Crittenden MD, Al-Tabbaa AK, Khuri SF. Intraoperative Regional Myocardial Acidosis Predicts the Need for Inotropic Support During Cardiac Surgery. Am J Surg 2004:188(5):474-480.

4Kumbhani DJ, Healey NA, Thatte H, Crittenden MD, Birjiniuk V, Treanor PR, Khuri SF. Readmission After cardiac surgery: The role of intraoperative myocardial acidosis. J Am Coll Surg 2004;199(3S):71.
© Copyright 2008 Terumo Cardiovascular Systems, Corp. All rights reserved.
Home Site Map Notices and Disclaimers Privacy Policy